王佳宁 博士,研究员,博导、硕导
-研究方向超高分辨分子质谱成像体系与装置
-招生学科海洋科学
-邮  箱jianingwang@hainanu.edu.cn /justin.wang.4in1@gmail.com

1. Xie C, Wang J*, Guo L, Diao X, Lam TK, Chen Y, Li R, Zhang Y, Wang X, Fang J, Yao Z, Dreisewerd K*, Cai Z* (2026) Tenfold Expansion Submicrometer MALDI Mass Spectrometry Imaging of Tissues and Cultured Cells. Angewandte Chemie International Edition, :e1256471.

2. Wang X, Han J, Diao X, Wang X, Zeng C, Li Y, Wang J*, Cai Z, Wei Z* (2026) Rational Control of Interfacial Spontaneous Redox Reactions by Modulating Single-Microdroplet Charging. Analytical Chemistry, 98(1):850–859.

3. Wang L, Xie C, Guo L*, Lam TKY, Wong CKC, Shah M, Xu X, Wang J*, Xu J*, Dong J, Cai Z (2026) prepIMS: a robust data preprocessing workflow for ion mobility mass spectrometry imaging. Analytica Chimica Acta, 1384:344951.

4. Chen Y, Shi R, Wang J*, Xie C, Song Y, Li R, Wen L, Lam TK-Y, Yang Z, Cai Z* (2025) Single-Cell 5 μm-Resolution Dual-Polarity MALDI-MS Imaging without Matrix Reapplication. Analytical Chemistry, 97(31):17167–17174.

5. Diao X, Wang J*, Xie C, Chen L, Lam KY, Zhu L, Cai Z* (2025) Comprehensive High Spatial Resolution Imaging Metabolomics Workflow for Heterogeneous Tissues. Analytical Chemistry, 97(20):10561–10569.

6. Chen Y, Song Y, Yang Z, Ru Y, Xie P, Han J, Chai X, Wang J*, Cai Z* (2025) Optimized MALDI2-Mass Spectrometry Imaging for Stable Isotope Tracing of Tissue-Specific Metabolic Pathways in Mice. Analytical Chemistry, 97(1):499–507.

7. Hung YLW, Xie C, Wang J*, Diao X, Li R, Wang X, Qiu S, Fang J, Cai Z* (2024) Expansion Strategy-Driven Micron-Level Resolution Mass Spectrometry Imaging of Lipids in Mouse Brain Tissue. CCS Chemistry, 6(11):2662–2670.

8. Xie C, Wang J*, Diao X, Guo L, Lam TK-Y, Li R, Chen Y, Zhang Y, Wang X, Fang J, Cai Z* (2024) Ten-Fold Expansion MALDI Mass Spectrometry Imaging of Tissues and Cells at 500 nm Resolution. bioRxiv, :2024.10.20.619316. https://doi.org/10.1101/2024.10.20.619316

9. Wang J, Li S, Yang L, Kwan C, Xie C, Cheung KY, Sun RW, Chan ASC, Huang Z*, Cai Z*, Zeng T*, Leung KC* (2024) Janus and Amphiphilic MoS2 2D Sheets for Surface-Directed Orientational Assemblies toward Ex Vivo Dual Substrate Release. Small Methods, 8(12):2400533.

10. Guo L, Xie C, Miao R, Xu J, Xu X, Fang J, Wang X, Liu W, Liao X*, Wang J*, Dong J*, Cai Z* (2024) DeepION: A Deep Learning-Based Low-Dimensional Representation Model of Ion Images for Mass Spectrometry Imaging. Analytical Chemistry, 96(9):3829–3836.

11. Xie C, Chen Y, Wang X, Song Y, Shen Y, Diao X, Zhu L, Wang J*, Cai Z* (2022) Chiral derivatization-enabled discrimination and on-tissue detection of proteinogenic amino acids by ion mobility mass spectrometry. Chemical Science, 13(47):14114–14123.

12. Chen Y, Xie C, Wang X, Cao G, Ru Y, Song Y, Iyaswamy A, Li M, Wang J*, Cai Z* (2022) 3‑Acetylpyridine On-Tissue Paternò–Büchi Derivatization Enabling High Coverage Lipid C=C Location-Resolved MS Imaging in Biological Tissues. Analytical Chemistry, 94(44):15367–15376.

13. Diao X, Xie C, Xie G, Song Y, Liang Y, Li R, Dong C, Zhu L*, Wang J*, Cai Z* (2022) Mass Spectrometry Imaging Revealed Sulfatides Depletion in Brain Tissues of Rats Exposed in Real Air with High Fine Particulate Matter. Environmental Science & Technology Letters, 9(10):856–862.

14. Chen Y, Jiang L, Zhang R, Shi Z, Xie C, Hong Y, Wang J*, Cai Z (2022) Spatially revealed perfluorooctane sulfonate-induced nephrotoxicity in mouse kidney using atmospheric pressure MALDI mass spectrometry imaging. Science of The Total Environment, 838(Pt 3):156380.

15. Zeng T, Zhang R, Chen Y, Guo W, Wang J*, Cai Z* (2022) In situ localization of lipids on mouse kidney tissues with acute cadmium toxicity using atmospheric pressure-MALDI mass spectrometry imaging. Talanta, 245:123466.

16. Wang, J., Han, X*. Analytical challenges of shotgun lipidomics at different resolution of measurements. TrAC-Trend Anal Chem, 121,115697, (2019)

17. Wang, J., Wang, C. & Han, X*. Tutorial on lipidomics. Anal Chim Acta, 1061, 28-41, (2019).

18. Wang, J., Wang, C. & Han, X*. Enhanced coverage of lipid analysis and imaging by matrix-assisted laser desorption/ionization mass spectrometry via a strategy with an optimized mixture of matrices. Anal Chim Acta 1000, 155-162, (2018).

19. Wang, J., Sun, J., Wang, J., Liu, H., Xue, J. & Nie, Z*. Hexagonal boron nitride nanosheets as a multifunctional background-free matrix to detect small molecules and complicated samples by MALDI mass spectrometry. Chem Commun 53, 8114-8117, (2017) (Cover Story).

20. Wang, J., Qiu, S., Chen, S., Xiong, C., Liu, H., Wang, J., Zhang, N., Hou, J., He, Q. & Nie, Z*. MALDI-TOF MS imaging of metabolites with a N-(1-naphthyl) ethylenediamine dihydrochloride matrix and its application to colorectal cancer liver metastasis. Anal Chem 87, 422-430, (2015).

21. Guo L, Zhu X, Shi Z, Lam TK-Y, Wang J, Dong J#, Cai Z# (2026) AI-Driven Computational Enhancement of Mass Spectrometry Imaging: Detection Sensitivity, Spatial Resolution, Molecular Coverage, and Acquisition Throughput. TrAC Trends in Analytical Chemistry, :119132. https://doi.org/10.1016/j.trac.2026.119132

22. Shi Z, Nie J, Chen Z, Lam TK, Wang J, Guo L, Li Y, Cui C, Ying H, Zhang J, Cai X, Zeng Q, Chen Y, Lin S, Zheng L, Cai Z* (2026) Synergistically Activating N 2 and CO 2 at Water Microdroplet Interfaces. Angewandte Chemie International Edition, 65(3):e19068.

23. Zhang MS, Kwan KK-L, Tse AP-W, Wang G, Wei LL, Sun K, Chui NN-Q, Lee D, Bao MH-R, Pang X, Wu Z, Chen Y, Wang Y, Yang Z, Jiang X, Li Q, Zhang Y, Zhong Y, Cheu JW-S, Chen Y, Li W, Wong C-M, Wang J, Cai Z, Zhang Q, Liang T, Ng IO-L, Papathanassiu AE, Wong CC-L* (2026) BCAT1-dependent HIF-1α stabilization is a targetable metabolic vulnerability in hepatocellular carcinoma. Cell reports. Medicine, :102784.

24. Zhu L*, Diao X, Yuan C, Lau CML, Wang J, Wu W, Mobasheri A, Houard X, Wen C*, Cai Z* (2025) Integrative spatially resolved proteomic and metabolomic imaging reveals synovitis endotypes implicated in osteoarthritis progression. Theranostics, 15(18):9729–9741.

25. Guo L, Xie C, Diao X, Lam TKY, Zhong Y, Chen Y, Xu J, Xu X, Zhu X, Xiong Z, Luo S, Wang J, Dong J*, Cai Z* (2025) De-MSI: A Deep Learning-Based Data Denoising Method to Enhance Mass Spectrometry Imaging by Leveraging the Chemical Prior Knowledge. Analytical chemistry, 97(37):20201–20208.

26. Guo L, Xie P, Shen X, Lam TKY, Deng L, Xie C, Xu X, Wong CKC, Xu J, Fang J, Wang X, Xiong Z, Luo S, Wang J, Dong J*, Cai Z* (2025) Unraveling Spatial Heterogeneity in Mass Spectrometry Imaging Data with GraphMSI. Advanced Science, 12(8):2410840.

27. Shi R, Chen Y, Wu W, Diao X, Chen L, Liu X, Wu H, Wang J, Zhu L*, Cai Z* (2025) Mass Spectrometry-Based Spatial Multiomics Revealed Bioaccumulation Preference and Region-Specific Responses of PFOS in Mice Cardiac Tissue. Environmental Science & Technology, 59(4):1957–1968.

28. Shen Y, Wang Y, Wang J, Xie P, Xie C, Chen Y, Banaei N, Ren K*, Cai Z* (2024) High-resolution 3D spatial distribution of complex microbial colonies revealed by mass spectrometry imaging. Journal of Advanced Research, 73:329–340.

29. Zhou Y, Li C, Chen Y, Yu Y, Diao X, Chiu R, Fang J, Shen Y, Wang J, Zhu L*, Zhou J*, Cai Z* (2024) Human Airway Organoids and Multimodal Imaging-Based Toxicity Evaluation of 1‑Nitropyrene. Environmental Science & Technology, 58(14):6083–6092.

30. Guo L, Zhu J, Wang K, Cheng K-K, Xu J, Dong L, Xu X, Chen C, Shah M, Peng Z, Wang J, Cai Z, Dong J* (2023) Multimodal Image Fusion Offers Better Spatial Resolution for Mass Spectrometry Imaging. Analytical Chemistry, 95(25):9714–9721.

31. Qiu S, Palavicini JP, Wang J, Gonzalez NS, He S, Dustin E, Zou C, Ding L, Bhattacharjee A, Skike CEV, Galvan V, Dupree JL, Han X* (2021) Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer’s disease-like neuroinflammation and cognitive impairment. Molecular Neurodegeneration, 16(1):64.

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33. He, Q., Badu-Tawiah, A. K., Chen, S., Xiong, C., Liu, H., Zhou, Y., Hou, J., Zhang, N., Li, Y., Xie, X., Wang, J., Mao, L. & Nie, Z*. In situ bioconjugation and ambient surface modification using reactive charged droplets. Anal Chem 87, 3144-3148, (2015).

34. Liu, H., Chen, R., Wang, J., Chen, S., Xiong, C., Wang, J., Hou, J., He, Q., Zhang, N., Nie, Z*. & Mao, L*. 1,5-Diaminonaphthalene hydrochloride assisted laser desorption/ionization mass spectrometry imaging of small molecules in tissues following focal cerebral ischemia. Anal Chem 86, 10114-10121, (2014).

35. Xiong, C., Zhou, X., Wang, J., Zhang, N., Peng, W. P., Chang, H. C. & Nie, Z*. Ambient aerodynamic desorption/ionization method for microparticle mass measurement. Anal Chem 85, 4370-4375, (2013).

36. Chen, S., Zheng, H., Wang, J., Hou, J., He, Q., Liu, H., Xiong, C., Kong, X. & Nie, Z*. Carbon nanodots as a matrix for the analysis of low-molecular-weight molecules in both positive- and negative-ion matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and quantification of glucose and uric acid in real samples. Anal Chem 85, 6646-6652, (2013).

37. Chen, S., Chen, L., Wang, J., Hou, J., He, Q., Liu, J., Wang, J., Xiong, S., Yang, G. & Nie, Z*. 2,3,4,5-Tetrakis(3',4'-dihydroxylphenyl)thiophene: a new matrix for the selective analysis of low molecular weight amines and direct determination of creatinine in urine by MALDI-TOF MS. Anal Chem 84, 10291-10297, (2012).

38. Wang J, Wang C, Han X (2021) Mass Spectrometry-Based Shotgun Lipidomics for Cancer Research, in Cancer Metabolomics, Methods and Applications, ISBN 978-3-030-51652-9. Springer.