1.Chen Y, Shi R, Wang J#, Xie C, Song Y, Li R, Wen L, Lam TK-Y, Yang Z, Cai Z# (2025) Single-Cell 5 μm-Resolution Dual-Polarity MALDI-MS Imaging without Matrix Reapplication. Analytical Chemistry, 97(31):17167–17174.

2.Diao X, Wang J#, Xie C, Chen L, Lam KY, Zhu L, Cai Z# (2025) Comprehensive High Spatial Resolution Imaging Metabolomics Workflow for Heterogeneous Tissues. Analytical Chemistry, 97(20):10561–10569.

3.Chen Y, Song Y, Yang Z, Ru Y, Xie P, Han J, Chai X, Wang J#, Cai Z# (2025) Optimized MALDI2-Mass Spectrometry Imaging for Stable Isotope Tracing of Tissue-Specific Metabolic Pathways in Mice. Analytical Chemistry, 97(1):499–507.

4.Guo L, Xie C, Diao X, Lam TKY, Zhong Y, Chen Y, Xu J, Xu X, Zhu X, Xiong Z, Luo S, Wang J, Dong J#, Cai Z# (2025) De-MSI: A Deep Learning-Based Data Denoising Method to Enhance Mass Spectrometry Imaging by Leveraging the Chemical Prior Knowledge. Analytical chemistry, 97(37):20201–20208.

5.Wang F, Chen Y, Lin S, Wang X, Su X, Cao G, Zhang J, Dai Q, Wang J, Yan H#, Cai Z# (2025) Spatial lipidomics and metabolomics reveal brain region-specific metabolic dysregulation in mice exposed to the emerging persistent organic pollutant methoxychlor. Journal of Hazardous Materials, 497:139601.

6.Chen Y, Xu J, LAM TK-Y, Xie Y, Wang J, Xiong A, Wang Z, Cai Z, Li L#, Yang L# (2025) Unraveling pyrrolizidine alkaloid-induced liver damage with an integrative spatial lipidomics framework. Journal of Pharmaceutical Analysis, :101340.

7.Guo L, Xie P, Shen X, Lam TKY, Deng L, Xie C, Xu X, Wong CKC, Xu J, Fang J, Wang X, Xiong Z, Luo S, Wang J, Dong J#, Cai Z# (2025) Unraveling Spatial Heterogeneity in Mass Spectrometry Imaging Data with GraphMSI. Advanced Science, 12(8):2410840.

8.Zhang B, Lam TKY, Chen L, Zhang C, Zhu L, Zhang H, Wang P, Wang J, Cai Z#, Xia Y# (2025) Single-cell transcriptomics and time-series metabolite profiling reveal the spatiotemporal regulation of flavonoid biosynthesis genes and phytohormone homeostasis by PAP1 in Arabidopsis. BMC Biology, 23(1):191.

9.Lee WK, Wan HT, Cheng Z, Chan WY, Lam TKY, Lai KP, Wang J, Cai Z, Wong CKC# (2025) Impact of PFOS Exposure on Murine Fetal Hematopoietic Stem Cells, Associated with Intrauterine Metabolic Perturbation. Environmental Science & Technology, 59(11):5496–5509.

10.Shi R, Chen Y, Wu W, Diao X, Chen L, Liu X, Wu H, Wang J, Zhu L#, Cai Z# (2025) Mass Spectrometry-Based Spatial Multiomics Revealed Bioaccumulation Preference and Region-Specific Responses of PFOS in Mice Cardiac Tissue. Environmental Science & Technology, 59(4):1957–1968.

11.Xie C, Wang J#, Diao X, Wang X, Cai Z# (2024) Single-Cell Resolution DESI Mass Spectrometry Imaging through 10-Fold Sample Expansion. bioRxiv, :2024.10.21.619369. https://doi.org/10.1101/2024.10.21.619369

12.Xie C, Wang J#, Diao X, Guo L, Lam TK-Y, Li R, Chen Y, Zhang Y, Wang X, Fang J, Cai Z# (2024) Ten-Fold Expansion MALDI Mass Spectrometry Imaging of Tissues and Cells at 500 nm Resolution. bioRxiv, :2024.10.20.619316. https://doi.org/10.1101/2024.10.20.619316

13.Shen Y, Wang Y, Wang J, Xie P, Xie C, Chen Y, Banaei N, Ren K#, Cai Z# (2024) High-resolution 3D spatial distribution of complex microbial colonies revealed by mass spectrometry imaging. Journal of Advanced Research, 73:329–340.

14.Hung YLW, Xie C, Wang J#, Diao X, Li R, Wang X, Qiu S, Fang J, Cai Z# (2024) Expansion Strategy-Driven Micron-Level Resolution Mass Spectrometry Imaging of Lipids in Mouse Brain Tissue. CCS Chemistry, 6(11):2662–2670.

15.Wang J, Li S, Yang L, Kwan C, Xie C, Cheung KY, Sun RW, Chan ASC, Huang Z#, Cai Z#, Zeng T#, Leung KC# (2024) Janus and Amphiphilic MoS2 2D Sheets for Surface-Directed Orientational Assemblies toward Ex Vivo Dual Substrate Release. Small Methods, 8(12):2400533.

16.Zhou Y, Li C, Chen Y, Yu Y, Diao X, Chiu R, Fang J, Shen Y, Wang J, Zhu L#, Zhou J#, Cai Z# (2024) Human Airway Organoids and Multimodal Imaging-Based Toxicity Evaluation of 1‑Nitropyrene. Environmental Science & Technology, 58(14):6083–6092.

17.Guo L, Xie C, Miao R, Xu J, Xu X, Fang J, Wang X, Liu W, Liao X#, Wang J#, Dong J#, Cai Z# (2024) DeepION: A Deep Learning-Based Low-Dimensional Representation Model of Ion Images for Mass Spectrometry Imaging. Analytical Chemistry, 96(9):3829–3836.

18.Qiu S, He S, Wang J, Wang H, Bhattacharjee A, Li X, Saeed M, Dupree JL, Han X# (2023) Adult-Onset CNS Sulfatide Deficiency Causes Sex-Dependent Metabolic Disruption in Aging. International Journal of Molecular Sciences, 24(13):10483.

19.Guo L, Zhu J, Wang K, Cheng K-K, Xu J, Dong L, Xu X, Chen C, Shah M, Peng Z, Wang J, Cai Z, Dong J# (2023) Multimodal Image Fusion Offers Better Spatial Resolution for Mass Spectrometry Imaging. Analytical Chemistry, 95(25):9714–9721.

20.Xie C, Chen Y, Wang X, Song Y, Shen Y, Diao X, Zhu L, Wang J#, Cai Z# (2022) Chiral derivatization-enabled discrimination and on-tissue detection of proteinogenic amino acids by ion mobility mass spectrometry. Chemical Science, 13(47):14114–14123.

21.Chen Y, Xie C, Wang X, Cao G, Ru Y, Song Y, Iyaswamy A, Li M, Wang J#, Cai Z# (2022) 3‑Acetylpyridine On-Tissue Paternò–Büchi Derivatization Enabling High Coverage Lipid C=C Location-Resolved MS Imaging in Biological Tissues. Analytical Chemistry, 94(44):15367–15376.

22.Diao X, Xie C, Xie G, Song Y, Liang Y, Li R, Dong C, Zhu L#, Wang J#, Cai Z# (2022) Mass Spectrometry Imaging Revealed Sulfatides Depletion in Brain Tissues of Rats Exposed in Real Air with High Fine Particulate Matter. Environmental Science & Technology Letters, 9(10):856–862.

23.Chen Y, Jiang L, Zhang R, Shi Z, Xie C, Hong Y, Wang J#, Cai Z (2022) Spatially revealed perfluorooctane sulfonate-induced nephrotoxicity in mouse kidney using atmospheric pressure MALDI mass spectrometry imaging. Science of The Total Environment, 838(Pt 3):156380.

24.Zeng T, Zhang R, Chen Y, Guo W, Wang J#, Cai Z# (2022) In situ localization of lipids on mouse kidney tissues with acute cadmium toxicity using atmospheric pressure-MALDI mass spectrometry imaging. Talanta, 245:123466.

25.Xie P, Zhang J, Wu P, Wu Y, Hong Y, Wang J, Cai Z# (2023) Multicellular tumor spheroids bridge the gap between two-dimensional cancer cells and solid tumors: The role of lipid metabolism and distribution. Chinese Chemical Letters, 34(2):107349.

26.Qiu S, Palavicini JP, Wang J, Gonzalez NS, He S, Dustin E, Zou C, Ding L, Bhattacharjee A, Skike CEV, Galvan V, Dupree JL, Han X# (2021) Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer’s disease-like neuroinflammation and cognitive impairment. Molecular Neurodegeneration, 16(1):64.

27.Chen Y, Wang T, Xie P, Song Y, Wang J, Cai Z# (2021) Mass spectrometry imaging revealed alterations of lipid metabolites in multicellular tumor spheroids in response to hydroxychloroquine. Analytica Chimica Acta, 1184:339011.